Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC5200939 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Tong Yin Y Li Zhoufang Z Zhang Hua H Xia Ligang L Zhang Meng M Xu Ying Y Wang Zhanhui Z Deem Michael W MW Sun Xiaojuan X He Jiankui J
Genomics, proteomics & bioinformatics 20161224 6
Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors (TCRs), we used a high-throughput immune repertoire sequencing technique to profile the spectrum of TCRs in individual T1D patients and controls. We sequenced the T cell repertoire of nine T1D patients, four type 2 diabetes (T2D) patients, and six nondiabetic control ...[more]