How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review.

ABSTRACT: Background. Fear of adverse events and occurrence of side effects are commonly cited by families and physicians as obstructive to appropriate use of pain medication in children. We examined evidence comparing the safety profiles of three groups of oral medications, acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids, to manage acute nonsurgical pain in children (<18 years) treated in ambulatory settings. Methods. A comprehensive search was performed to July 2015, including review of national data registries. Two reviewers screened articles for inclusion, assessed methodological quality, and extracted data. Risks (incidence rates) were pooled using a random effects model. Results. Forty-four studies were included; 23 reported on adverse events. Based on lim

SUBMITTER: Hartling L 

PROVIDER: S-EPMC5203901 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature