Identification of loci affecting teat number by genome-wide association studies on three pig populations.
Ontology highlight
ABSTRACT: Objective
Three genome-wide association studies (GWAS) and a meta-analysis of GWAS were conducted to explore the genetic mechanisms underlying variation in pig teat number.Methods
We performed three GWAS and a meta-analysis for teat number on three pig populations, including a White Duroc×Erhualian F2 resource population (n = 1,743), a Chinese Erhualian pig population (n = 320) and a Chinese Sutai pig population (n = 383).Results
We detected 24 single nucleotide polymorphisms (SNPs) that surpassed the genome-wide significant level on Sus Scrofa chromosomes (SSC) 1, 7, and 12 in the F2 resource population, corresponding to four loci for pig teat number. We highlighted vertnin (VRTN) and lysine demethylase 6B (KDM6B) as two interesting candidate genes at the loci on SSC7 and SSC12. No significant associated SNPs were identified in the meta-analysis of GWAS.Conclusion
The results verified the complex genetic architecture of pig teat number. The causative variants for teat number may be different in the three populations.
SUBMITTER: Tang J
PROVIDER: S-EPMC5205583 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of loci affecting teat number by genome-wide association studies on three pig populations.
Tang Jianhong J Zhang Zhiyan Z Yang Bin B Guo Yuanmei Y Ai Huashui H Long Yi Y Su Ying Y Cui Leilei L Zhou Liyu L Wang Xiaopeng X Zhang Hui H Wang Chengbin C Ren Jun J Huang Lusheng L Ding Nengshui N
Asian-Australasian journal of animal sciences 20160422 1
<h4>Objective</h4>Three genome-wide association studies (GWAS) and a meta-analysis of GWAS were conducted to explore the genetic mechanisms underlying variation in pig teat number.<h4>Methods</h4>We performed three GWAS and a meta-analysis for teat number on three pig populations, including a White Duroc×Erhualian F<sub>2</sub> resource population (n = 1,743), a Chinese Erhualian pig population (n = 320) and a Chinese Sutai pig population (n = 383).<h4>Results</h4>We detected 24 single nucleotid ...[more]
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