Dataset Information

Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets.

ABSTRACT:

Objective

The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets.

Methods

A total of 180 barrows with initial weight 10.01±0.03 kg were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), respectively.

Results

The results showed that in comparison with control diet, dietary Ala-Gln supplementation increased the height of villi in duodenum and jejunum (p<0.05), Gln supplementation increased the villi height of jejunum (p<0.05), Ala-Gln supplementation up-regulated the mRNA expressions of epidermal growth factor receptor and insulin-like growth factor 1 receptor in jejunal mucosa (p<0.05), raised the mRNA expressions of Claudin-1, Occludin, zonula occludens protein-1 (ZO-1) and the protein levels of Occludin, ZO-1 in jejunal mucosa (p<0.05), Ala-Gln supplementation enlarged the number of goblet cells in duodenal and ileal epithelium (p<0.05), Gln increased the number of goblet cells in duodenal epithelium (p<0.05) and Ala-Gln supplementation improved the concentrations of secretory immunoglobulin A and immunoglobulin G in the jejunal mucosa (p<0.05).

Conclusion

These results demonstrated that dietary Ala-Gln supplementation could maintain the integrity of small intestine and promote the functions of intestinal mucosa barriers in piglets.

SUBMITTER: Xing S

PROVIDER: S-EPMC5205612 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Publications

Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets.

Xing Shen S Zhang Bolin B Lin Meng M Zhou Ping P Li Jiaolong J Zhang Lin L Gao Feng F Zhou Guanghong G

Asian-Australasian journal of animal sciences 20160630 2

<h4>Objective</h4>The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets.<h4>Methods</h4>A total of 180 barrows with initial weight 10.01±0.03 kg were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), re ...[more]

PMID: 27383799

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Dataset Information

Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets.

Objective

Methods

Results

Conclusion

Publications

Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets.

Similar Datasets

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