Mathematical modeling of Myosin induced bistability of Lamellipodial fragments.
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ABSTRACT:
SUBMITTER: Hirsch S
PROVIDER: S-EPMC5206284 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Mathematical modeling of Myosin induced bistability of Lamellipodial fragments.
Hirsch S S Manhart A A Schmeiser C C
Journal of mathematical biology 20160425 1-2
For various cell types and for lamellipodial fragments on flat surfaces, externally induced and spontaneous transitions between symmetric nonmoving states and polarized migration have been observed. This behavior is indicative of bistability of the cytoskeleton dynamics. In this work, the Filament Based Lamellipodium Model (FBLM), a two-dimensional, anisotropic, two-phase continuum model for the dynamics of the actin filament network in lamellipodia, is extended by a new description of actin-myo ...[more]
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