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Independent natural genetic variation of punishment- versus relief-memory.

ABSTRACT: A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment- versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment- and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.

SUBMITTER: Appel M

PROVIDER: S-EPMC5206585 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Independent natural genetic variation of punishment- versus relief-memory.

Appel Mirjam M Scholz Claus-Jürgen CJ Kocabey Samet S Savage Sinead S König Christian C Yarali Ayse A

Biology letters 20161201 12

A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment- versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment- and relief-memories di ...[more]

PMID: 28003518

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