Ontology highlight
ABSTRACT:
SUBMITTER: Shanmugasundaram U
PROVIDER: S-EPMC5206687 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
AIDS research and human retroviruses 20100919 10
Variation of the HIV-1 subtype C reverse transcriptase region (RT) resulting in response to the selective pressures of drug therapy remains poorly characterized. Here, we compared the genetic variation resulting in the presence and absence of antiretroviral drug selective pressures on HIV-1 subtype C RT among nontreated and treated patients. The nucleotide variability, nonsynonymous and synonymous ratio, and the positively selected mutations were determined by comparing the RT sequences isolated ...[more]