Mechanical stress activates NMDA receptors in the absence of agonists.
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ABSTRACT:
SUBMITTER: Maneshi MM
PROVIDER: S-EPMC5206744 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Mechanical stress activates NMDA receptors in the absence of agonists.
Maneshi Mohammad Mehdi MM Maki Bruce B Gnanasambandam Radhakrishnan R Belin Sophie S Popescu Gabriela K GK Sachs Frederick F Hua Susan Z SZ
Scientific reports 20170103
While studying the physiological response of primary rat astrocytes to fluid shear stress in a model of traumatic brain injury (TBI), we found that shear stress induced Ca<sup>2+</sup> entry. The influx was inhibited by MK-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurred in the absence of agonists. Other NMDA open channel blockers ketamine and memantine showed a similar effect. The competitive glutamate antagonists AP5 and GluN2B-selective inh ...[more]
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