A Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury.
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ABSTRACT:
SUBMITTER: de Almeida DC
PROVIDER: S-EPMC5206861 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
A Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury.
de Almeida Danilo Candido DC Bassi Ênio Jose ÊJ Azevedo Hatylas H Anderson Letícia L Origassa Clarice Silvia Taemi CS Cenedeze Marcos Antônio MA de Andrade-Oliveira Vinicius V Felizardo Raphael José Ferreira RJ da Silva Reinaldo Correia RC Hiyane Meire Ioshie MI Semedo Patricia P Dos Reis Marlene Antônia MA Moreira-Filho Carlos Alberto CA Verjovski-Almeida Sergio S Pacheco-Silva Álvaro Á Câmara Niels Olsen Saraiva NO
Frontiers in immunology 20170103
Mesenchymal stromal cells (MSCs) orchestrate tissue repair by releasing cell-derived microvesicles (MVs), which, presumably by small RNA species, modulate global gene expression. The knowledge of miRNA/mRNA signatures linked to a reparative status may elucidate some of the molecular events associated with MSC protection. Here, we used a model of cisplatin-induced kidney injury (acute kidney injury) to assess how MSCs or MVs could restore tissue function. MSCs and MVs presented similar protective ...[more]
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