Ontology highlight
ABSTRACT:
SUBMITTER: Fu D
PROVIDER: S-EPMC5206904 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Fu Dragony D Samson Leona D LD Hübscher Ullrich U van Loon Barbara B
DNA repair 20150914
Human AlkB homolog 2 (ALKBH2) is a DNA repair enzyme that catalyzes the direct reversal of DNA methylation damage through oxidative demethylation. While ALKBH2 colocalizes with proliferating cell nuclear antigen (PCNA) in DNA replication foci, it remains unknown whether these two proteins alone form a complex or require additional components for interaction. Here, we demonstrate that ALKBH2 can directly interact with PCNA independent from other cellular factors, and we identify the hydrophobic p ...[more]