Parental rheumatoid arthritis and childhood epilepsy: A nationwide cohort study.

ABSTRACT:

Objective

To assess the influence of parental rheumatoid arthritis (RA) on risk of epilepsy.

Methods

We performed a nationwide cohort study including all singletons born in Denmark from 1977 to 2008 (n = 1,917,723) through individual linkage to nationwide Danish registries. The children were followed for an average of 16 years. Main outcome measures were adjusted hazard ratios (HRs) for epilepsy with onset in early childhood (29 days-4 years), late childhood (5-15 years), adolescence/adulthood (≥15 years), and at any age until the end of follow-up (December 31, 2010).

Results

Compared to unexposed children, children exposed to maternal RA had an increased risk of early and late childhood epilepsy (adjusted HRs 1.34 [95% confidence interval (CI) 1.13-1.60] and 1.26 [95

SUBMITTER: Rom AL 

PROVIDER: S-EPMC5206999 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature