Ontology highlight
ABSTRACT:
SUBMITTER: Payne JM
PROVIDER: S-EPMC5207004 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Payne Jonathan M JM Barton Belinda B Ullrich Nicole J NJ Cantor Alan A Hearps Stephen J C SJ Cutter Gary G Rosser Tena T Walsh Karin S KS Gioia Gerard A GA Wolters Pamela L PL Tonsgard James J Schorry Elizabeth E Viskochil David D Klesse Laura L Fisher Michael M Gutmann David H DH Silva Alcino J AJ Hunter Scott J SJ Rey-Casserly Celiane C Cantor Nancy L NL Byars Anna W AW Stavinoha Peter L PL Ackerson Joseph D JD Armstrong Carol L CL Isenberg Jill J O'Neil Sharon H SH Packer Roger J RJ Korf Bruce B Acosta Maria T MT North Kathryn N KN
Neurology 20161109 24
<h4>Objective</h4>To assess the efficacy of lovastatin on visuospatial learning and attention for treating cognitive and behavioral deficits in children with neurofibromatosis type 1 (NF1).<h4>Methods</h4>A multicenter, international, randomized, double-blind, placebo-controlled trial was conducted between July 2009 and May 2014 as part of the NF Clinical Trials Consortium. Children with NF1 aged 8-15 years were screened for visuospatial learning or attention deficits (n = 272); 146 children dem ...[more]