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Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation.

ABSTRACT: Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the ?2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.

SUBMITTER: Duc NM

PROVIDER: S-EPMC5207459 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation.

Duc Nguyen Minh NM Kim Hee Ryung HR Chung Ka Young KY

Biomolecules & therapeutics 20170101 1

Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adreno ...[more]

PMID: 28035078

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