Ontology highlight
ABSTRACT:
SUBMITTER: O'Driscoll J
PROVIDER: S-EPMC520859 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
O'Driscoll Jonathan J Glynn Frances F Cahalane Oonagh O O'Connell-Motherway Mary M Fitzgerald Gerald F GF Van Sinderen Douwe D
Applied and environmental microbiology 20040901 9
A novel restriction-modification system, designated LlaJI, was identified on pNP40, a naturally occurring 65-kb plasmid from Lactococcus lactis. The system comprises four adjacent similarly oriented genes that are predicted to encode two m(5)C methylases and two restriction endonucleases. The LlaJI system, when cloned into a low-copy-number vector, was shown to confer resistance against representatives of the three most common lactococcal phage species. This phage resistance phenotype was found ...[more]