Ontology highlight
ABSTRACT:
SUBMITTER: McClure C
PROVIDER: S-EPMC5209283 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
McClure Clara C McPeak Melissa B MB Youssef Dima D Yao Zhi Q ZQ McCall Charles E CE El Gazzar Mohamed M
Immunology and cell biology 20160719 1
Myeloid-derived suppressor cells (MDSCs) increase late sepsis immunosuppression and mortality in mice. We reported that microRNA (miR) 21 and miR-181b expression in Gr1<sup>+</sup>CD11b<sup>+</sup> myeloid progenitors increase septic MDSCs in mice by arresting macrophage and dendritic cell differentiation. Here, we report how sepsis regulates miR-21 and miR-181b transcription. In vivo and in vitro binding studies have shown that C/EBPα transcription factor, which promotes normal myeloid cell dif ...[more]