Ontology highlight
ABSTRACT:
SUBMITTER: Mattson L
PROVIDER: S-EPMC5209614 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Journal of immunology research 20161219
Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4<su ...[more]