Intercalative DNA binding of the marine anticancer drug variolin B.
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ABSTRACT:
SUBMITTER: Canals A
PROVIDER: S-EPMC5209663 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Intercalative DNA binding of the marine anticancer drug variolin B.
Canals Albert A Arribas-Bosacoma Raquel R Albericio Fernando F Álvarez Mercedes M Aymamí Joan J Coll Miquel M
Scientific reports 20170104
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. ...[more]
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