Ontology highlight
ABSTRACT:
SUBMITTER: Park SY
PROVIDER: S-EPMC5209732 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Park Soo-Yeon SY Seo Jaesung J Choi Hyo-Kyoung HK Oh Hye-Jeong HJ Guk Garam G Lee Yoo-Hyun YH Lee Jeongmin J Jun Woo Jin WJ Choi Kyung-Chul KC Yoon Ho-Geun HG
Scientific reports 20170104
Programmed cell death 5 (PDCD5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how PDCD5 function is regulated during apoptosis remains obscure. Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to PDCD5 destabilization. Overexpression of wild-type PPEF-1, but not inactive PPEF-1<sup>D172N</sup>, efficiently suppressed CK2α-mediated stabilization of PDCD5 and p53-mediated apop ...[more]