Ontology highlight
ABSTRACT:
SUBMITTER: Lee NK
PROVIDER: S-EPMC5209736 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Lee Na Kyung NK Park Sang Eon SE Kwon Soo Jin SJ Shim Sangmi S Byeon Yeji Y Kim Jong-Hwa JH Na Duk L DL Chang Jong Wook JW
Scientific reports 20170104
The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulation of proteasome activity in AD. When SH-SY5Y human neuroblastoma cells were co-cultured with MSCs isolated from human Wharton's Jelly (WJ-MSC), their proteasome activity was signi ...[more]