Ontology highlight
ABSTRACT:
SUBMITTER: Antsiferova M
PROVIDER: S-EPMC5210090 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Antsiferova Maria M Piwko-Czuchra Aleksandra A Cangkrama Michael M Wietecha Mateusz M Sahin Dilara D Birkner Katharina K Amann Valerie C VC Levesque Mitchell M Hohl Daniel D Dummer Reinhard R Werner Sabine S
EMBO molecular medicine 20170101 1
Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functionally important, since activin promoted skin tumorigenesis in mice induced by the human papillomavirus 8 oncogenes. This was accompanied by depletion of epidermal γδ T cells and accumulation of regulatory T cells. Most importantly, activin increased the number o ...[more]