Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Iglesias AA
PROVIDER: S-EPMC5210247 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
López-Iglesias Ana-Alicia AA González-Méndez Lorena L San-Segundo Laura L Herrero Ana B AB Hernández-García Susana S Martín-Sánchez Montserrat M Gutiérrez Norma C NC Paíno Teresa T Avilés Pablo P Mateos María-Victoria MV San-Miguel Jesús F JF Garayoa Mercedes M Ocio Enrique M EM
Haematologica 20160818 1
Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment. This suggests that new molecules and combinations that may further inhibit important survival pathways for these tumor cells are needed. In this context, zalypsis is a novel compound, derived from marine organisms, with a powerful preclinical anti-myeloma effect based on the sensitivity of malignant plasma cells to DNA-damage induction; a ...[more]