Ontology highlight
ABSTRACT:
SUBMITTER: Mello CC
PROVIDER: S-EPMC521126 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Mello Cecilia C CC Barrick Doug D
Proceedings of the National Academy of Sciences of the United States of America 20040917 39
Energy landscapes have been used to conceptually describe and model protein folding but have been difficult to measure experimentally, in large part because of the myriad of partly folded protein conformations that cannot be isolated and thermodynamically characterized. Here we experimentally determine a detailed energy landscape for protein folding. We generated a series of overlapping constructs containing subsets of the seven ankyrin repeats of the Drosophila Notch receptor, a protein domain ...[more]