Ontology highlight
ABSTRACT:
SUBMITTER: Arts RJ
PROVIDER: S-EPMC5213309 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Arts Rob J W RJ Plantinga Theo S TS Tuit Sander S Ulas Thomas T Heinhuis Bas B Tesselaar Marika M Sloot Yvette Y Adema Gosse J GJ Joosten Leo A B LA Smit Johannes W A JW Netea Mihai G MG Schultze Joachim L JL Netea-Maier Romana T RT
Oncoimmunology 20160909 12
Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment in non-medullary thyroid cancer (TC), the most common endocrine malignancy. However, little is known regarding the regulation of their function in TC. Transcriptome analysis in a model of TC-induced macrophages identified increased inflammatory characteristics and rewiring of cell metabolism as key functional changes. This functional reprogramming was partly mediated by TC-derived lactate that induced upregulati ...[more]