Ontology highlight
ABSTRACT:
SUBMITTER: Cottat M
PROVIDER: S-EPMC5214100 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cottat Maximilien M Yasukuni Ryohei R Homma Yo Y Lidgi-Guigui Nathalie N Varin-Blank Nadine N Lamy de la Chapelle Marc M Le Roy Christine C
Scientific reports 20170105
Spleen Tyrosine Kinase (Syk) plays a crucial role in immune cell signalling and its altered expression or activation are involved in several cancers. Syk activity relies on its phosphorylation status and its multiple phosphorylation sites predict several Syk conformations. In this report, we characterized Syk structural changes according to its phosphorylation/activation status by Surface Enhanced Raman Spectroscopy (SERS). Unphosphorylated/inactive and phosphorylated/active Syk forms were produ ...[more]