Ontology highlight
ABSTRACT:
SUBMITTER: Yanagita T
PROVIDER: S-EPMC5214103 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Yanagita Tadahiko T Murata Yoji Y Tanaka Daisuke D Motegi Sei-Ichiro SI Arai Eri E Daniwijaya Edwin Widyanto EW Hazama Daisuke D Washio Ken K Saito Yasuyuki Y Kotani Takenori T Ohnishi Hiroshi H Oldenborg Per-Arne PA Garcia Noel Verjan NV Miyasaka Masayuki M Ishikawa Osamu O Kanai Yae Y Komori Takahide T Matozaki Takashi T
JCI insight 20170112 1
Tumor cells are thought to evade immune surveillance through interaction with immune cells. Much recent attention has focused on the modification of immune responses as a basis for new cancer treatments. SIRPα is an Ig superfamily protein that inhibits phagocytosis in macrophages upon interaction with its ligand CD47 expressed on the surface of target cells. Here, we show that SIRPα is highly expressed in human renal cell carcinoma and melanoma. Furthermore, an anti-SIRPα Ab that blocks the inte ...[more]