Ontology highlight
ABSTRACT:
SUBMITTER: Janic B
PROVIDER: S-EPMC5214587 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Janic Branislava B Bhuiyan Mohammed Pi MP Ewing James R JR Ali Meser M MM
ACS sensors 20160810 8
A hallmark of the tumor microenvironment in malignant tumor is extracellular acidosis, which can be exploited for targeted delivery of drugs and imaging agents. A pH sensitive paramagnetic nanoaparticle (NP) is developed by incorporating GdDOTA-4AmP MRI contrast agent and pHLIP (pH Low Insertion Peptide) into the surface of a G5-PAMAM dendrimer. pHLIP showed pH-selective insertion and folding into cell membranes, but only in acidic conditions. We demonstrated that pHLIP-conjugated Gd<sub>44</sub ...[more]