Ontology highlight
ABSTRACT:
SUBMITTER: Blum W
PROVIDER: S-EPMC5214595 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Blum W W Sanford B L BL Klisovic R R DeAngelo D J DJ Uy G G Powell B L BL Stock W W Baer M R MR Kolitz J E JE Wang E S ES Hoke E E Mrózek K K Kohlschmidt J J Bloomfield C D CD Geyer S S Marcucci G G Stone R M RM Larson R A RA
Leukemia 20160913 1
In this prospective phase 2 clinical trial conducted by Cancer and Leukemia Group B (CALGB, now the Alliance), we studied decitabine as maintenance therapy for younger adults with acute myeloid leukemia (AML) who remained in first complete remission (CR1) following intensive induction and consolidation. Given that decitabine is clinically active in AML and with hypomethylating activity distinct from cytotoxic chemotherapy, we hypothesized that 1 year of maintenance therapy would improve disease- ...[more]