Dataset Information

Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study.

ABSTRACT:

Background/aims

The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea.

Methods

A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The baseline disease characteristic and disease state at onset, treatment during the disease course were retrospectively reviewed among patients with young-onset (YO, < 20 years) and adult-onset (AO, ? 20 years). Severe outcome was defined as use of intravenous (IV) steroids, infliximab, immunosuppressant, or UC-related operation.

Results

There were 55 YO patients (mean age, 17.8 ± 2.4) and 1,086 AO patients (mean age, 43.0 ± 13.6). High Mayo scores (7.7 ± 3.0 vs. 5.6 ± 2.7, p = 0.000), extensive UC (52.7% vs. 25.8%, p = 0.000) and IV steroid (41.8% vs. 18.0%, p = 0.000), immunosuppressant (47.3% vs. 26.9%, p = 0.002), and infliximab (20.0% vs. 7.2%, p = 0.001) use were more frequent in the YO than in the AO group. According to multivariate analysis, severe outcomes were related to YO disease (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.71), body mass index < 23 kg/m² (HR, 1.46; 95% CI, 1.07 to 2.00), severe (HR, 2.29; 95% CI, 1.36 to 3.38), and moderate (HR, 2.48; 95% CI, 1.67 to 3.67) disease, extensive UC (HR, 2.90; 95% CI, 1.79 to 4.69), UC-related admission (HR, 63.89; 95% CI, 20.41 to 200.02), and oral steroid use (HR, 0.51; 95% CI, 0.39 to 0.67).

Conclusions

UC with YO presented with more advanced clinical features at onset and more severe outcomes than the AO. YO cases require careful management and intense treatment strategies.

SUBMITTER: Kim JY

PROVIDER: S-EPMC5214714 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Publications

Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study.

Kim Ji Yeon JY Park Dong Il DI Han Dong Soo DS Huh Kyu-Chan KC Lee Chang Kyun CK Shin Jeong Eun JE Kim Jae Hak JH Kim You Sun YS Jung Yunho Y Jung Sung-Ae SA Song Hyun Joo HJ Jang Hyun Joo HJ Kim Young-Ho YH Hong Sung No SN

The Korean journal of internal medicine 20160625 1

<h4>Background/aims</h4>The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea.<h4>Methods</h4>A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The baseline disease characteristic and disease state at onset, treatment during the disease course were retrospectively reviewed among patients with young-onset (YO, < 20 years) and adult-onse ...[more]

PMID: 27338135

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Dataset Information

Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study.

Background/aims

Methods

Results

Conclusions

Publications

Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study.

Similar Datasets

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