Autonomic dysfunction in primary Sjogren's syndrome: a prospective cohort analysis of 154 Korean patients.

ABSTRACT:

Background/aims

To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren's syndrome (pSS) and its associations with the clinical features of pSS.

Methods

We analyzed 154 participants from the Korean Initiative of primary Sjogren's Syndrome (KISS) as a prospective pSS cohort and 154 age- and sex-matched healthy controls. A standardized 5-minute, supine, resting heart rate variability (HRV) test was performed, and autonomic dysfunction was defined as standard deviation of normal-to-normal RR intervals (SDNN) < 30 ms in patients < 50 years old and SDNN < 20 ms in patients ≥ 50 years old. The associations between autonomic dysfunction and various clinical features of pSS were analyzed.

Results

The overall autonomic activity in patien

SUBMITTER: Koh JH 

PROVIDER: S-EPMC5214725 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature