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The effectiveness of pressure therapy (15-25?mmHg) for hypertrophic burn scars: A systematic review and meta-analysis.

ABSTRACT: Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains controversial. To clarify the effect of PT (15-25?mmHg) for HS, we performed the systematic review and meta-analysis. Several electronic databases were screened to identify related randomized controlled trials (RCTs). 12 RCTs involving 710 patients with 761 HS resulting from burn injuries were included. Compared with non/low-PT, cases treated with PT (15-25?mmHg) showed significant differences in Vancouver Scar Scale score (MD?=?-0.58, 95% CI?=?-0.78--0.37), thickness (SMD?=?-0.25, 95% CI?=?-0.40--0.11), brightness (MD?=?2.00, 95% CI?=?0.59-3.42), redness (MD?=?-0.79, 95% CI?=?-1.52--0.07), pigmentation (MD?=?-0.16, 95% CI?=?-0.32--0.00) and hardness (SMD?=?-0.65, 95% CI?=?-1.07--0.23). However, there was no difference in vascularity (MD?=?0.03, 95% CI?=?-0.43-0.48). Our analysis indicated that patients with HS who were managed with PT (15-25?mmHg) showed significant improvements. Due to limitations, more large and well-designed studies are needed to confirm our findings and the side-effects of the PT may also need to be evaluated.

SUBMITTER: Ai JW

PROVIDER: S-EPMC5215680 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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The effectiveness of pressure therapy (15-25 mmHg) for hypertrophic burn scars: A systematic review and meta-analysis.

Ai Jin-Wei JW Liu Jiang-Tao JT Pei Sheng-Duo SD Liu Yu Y Li De-Sheng DS Lin Hong-Ming HM Pei Bin B

Scientific reports 20170105

Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains controversial. To clarify the effect of PT (15-25 mmHg) for HS, we performed the systematic review and meta-analysis. Several electronic databases were screened to identify related randomized controlled trials (RCTs). 12 RCTs involving 710 patients with 761 HS resulting from burn injuries w ...[more]

PMID: 28054644

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Project description:ObjectiveThe aim of the study was to determine the longitudinal validity, reproducibility, responsiveness and interpretability of the adult version of the Brisbane Burn Scar Impact Profile, a patient-report measure of health-related quality of life.MethodsA prospective longitudinal cohort study of patients with or at risk of burn scarring was conducted at three assessment points (at baseline around the time of wound healing, one to two weeks post-baseline and 1-month post-baseline). Participants attending a major metropolitan adult burn centre at baseline were recruited. Participants completed the Brisbane Burn Scar Impact Profile and the 36-item Short Form Health Survey and Patient Observer Scar Assessment Scale. Intraclass Correlation Coefficients (ICCs), smallest detectable change, percentage of those who improved, stayed the same or worsened and Area under the Receiver Operating Characteristic Curve (AUC) were used to test the aim.ResultsData were included for 118 participants at baseline, 68 participants at one to two weeks and 57 participants at 1-month post-baseline. All groups of items had acceptable reproducibility, except for the overall impact of burn scars (ICC = 0.69), the impact of sensations which was not expected to be stable (ICC = 0.63), mobility and daily activities (ICC = 0.63, 0.67 respectively). The responsiveness of six out of seven groups of items able to be tested against external criterion was supported (AUC = 0.72-0.75). Hypothesised correlations of changes in the Brisbane Burn Scar Impact Profile items with changes in criterion measures generally supported longitudinal validity (e.g., nine out of thirteen hypotheses using the SF-36 as an external criterion were supported). Internal consistency estimates, item-total and inter-item correlations indicated there was likely redundancy of some groups of items, particularly in the relationships and social interaction, appearance and emotional reactions items (Chronbach's alpha range = 0.94-0.95).ConclusionSupport was found for the reproducibility, longitudinal validity, responsiveness and interpretability of most groups of Brisbane Burn Scar Impact Profile items and some individual items in the test population. Potential redundancy of items should be investigated further.

Dataset Information

The effectiveness of pressure therapy (15-25?mmHg) for hypertrophic burn scars: A systematic review and meta-analysis.

Publications

The effectiveness of pressure therapy (15-25 mmHg) for hypertrophic burn scars: A systematic review and meta-analysis.

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