Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC5215812 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Liu Shuhui S Zhao Kaitao K Su Xi X Lu Lu L Zhao He H Zhang Xianwen X Wang Yun Y Wu Chunchen C Chen Jizheng J Zhou Yuan Y Hu Xue X Wang Yanyi Y Lu Mengji M Chen Xinwen X Pei Rongjuan R
PloS one 20170105 1
An efficient clearance of hepatitis B virus (HBV) requires the coordinated work of both the innate and adaptive immune responses. MITA/STING, an adapter protein of the innate immune signaling pathways, plays a key role in regulating innate and adaptive immune responses to DNA virus infection. Previously, we identified an alternatively spliced isoform of MITA/STING, called MITA-related protein (MRP), and found that MRP could specifically block MITA-mediated interferon (IFN) induction while retain ...[more]