Ontology highlight
ABSTRACT:
SUBMITTER: Tischer T
PROVIDER: S-EPMC5215830 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Tischer Thomas T Schuh Melina M
Cell reports 20161001 5
Mammalian oocytes are stored in the ovary, where they are arrested in prophase for prolonged periods. The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood. Here, we identify and characterize an essential pathway for the resumption of meiosis that relies on the protein phosphatase DUSP7. DUSP7-depleted oocytes either fail to resume meiosis or resume meiosis with a significant delay. In the absence of DUSP7, Cdk1/CycB activity drops b ...[more]