Ontology highlight
ABSTRACT:
SUBMITTER: Nakamoto M
PROVIDER: S-EPMC5215901 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Nakamoto Masafumi M Ishihara Ko K Watanabe Takehisa T Hirosue Akiyuki A Hino Shinjiro S Shinohara Masanori M Nakayama Hideki H Nakao Mitsuyoshi M
PloS one 20170105 1
Glucocorticoid signaling through the glucocorticoid receptor (GR) plays essential roles in the response to stress and in energy metabolism. This hormonal action is integrated to the transcriptional control of GR-target genes in a cell type-specific and condition-dependent manner. In the present study, we found that the GR regulates the angiopoietin-like 4 gene (ANGPTL4) in a CCCTC-binding factor (CTCF)-mediated chromatin context in the human hepatic HepG2 cells. There are at least four CTCF-enri ...[more]