Parsing Heterogeneity in the Brain Connectivity of Depressed and Healthy Adults During Positive Mood.

ABSTRACT:

Background

There is well-known heterogeneity in affective mechanisms in depression that may extend to positive affect. We used data-driven parsing of neural connectivity to reveal subgroups present across depressed and healthy individuals during positive processing, informing targets for mechanistic intervention.

Methods

Ninety-two individuals (68 depressed patients, 24 never-depressed control subjects) completed a sustained positive mood induction during functional magnetic resonance imaging. Directed functional connectivity paths within a depression-relevant network were characterized using Group Iterative Multiple Model Estimation (GIMME), a method shown to accurately recover the direction and presence of connectivity paths in individual participants. During model selecti

SUBMITTER: Price RB 

PROVIDER: S-EPMC5215983 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature