In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications.
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ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC5216338 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications.
Hu Yun Y Sun Qinwei Q Liu Jie J Jia Yimin Y Cai Demin D Idriss Abdulrahman A AA Omer Nagmeldin A NA Zhao Ruqian R
Scientific reports 20170106
Betaine alleviates high-fat diet-induced fatty liver and prenatal betaine programs offspring hepatic lipid metabolism. Excessive corticosterone (CORT) exposure causes fatty liver in chickens, yet it remains unknown whether and how prenatal betaine modulates the susceptibility of CORT-induced fatty liver later in life. In this study, fertilized eggs were injected with saline or betaine before incubation, and the hatchlings were raised at 8 weeks of age followed by 7 days of subcutaneous CORT inje ...[more]
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