Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi M
PROVIDER: S-EPMC5216385 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170106
Ovo, which encodes a transcription factor with Zn-finger domains, is evolutionarily conserved among animals. In Drosophila, in addition to its zygotic function for egg production, maternal ovo activity is required in primordial germ cells (PGCs) for expression of germline genes such as vasa and nanos. In this study, we found that maternal Ovo accumulates in PGC nuclei during embryogenesis. In these cells, ovo serves a dual function: activation of genes expressed predominantly in PGCs, and conver ...[more]