Ontology highlight
ABSTRACT:
SUBMITTER: Lefort K
PROVIDER: S-EPMC5216996 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Lefort Karine K Ostano Paola P Mello-Grand Maurizia M Calpini Valérie V Scatolini Maria M Farsetti Antonella A Dotto G Paolo GP Chiorino Giovanna G
Oncotarget 20160701 30
Adenocarcinomas of the prostate arise as multifocal heterogeneous lesions as the likely result of genetic and epigenetic alterations and deranged cell-cell communication. Notch signaling is an important form of intercellular communication with a role in growth/differentiation control and tumorigenesis. Contrasting reports exist in the literature on the role of this pathway in prostate cancer (PCa) development. We show here that i) compared to normal prostate tissue, Notch1 expression is signific ...[more]