Ontology highlight
ABSTRACT:
SUBMITTER: Almaca J
PROVIDER: S-EPMC5217294 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Almaça Joana J Molina Judith J Menegaz Danusa D Pronin Alexey N AN Tamayo Alejandro A Slepak Vladlen V Berggren Per-Olof PO Caicedo Alejandro A
Cell reports 20161201 12
In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet. It is still unclear whether serotonin is relevant for regular islet physiology and hormone secretion. Here, we show that human beta cells produce and secrete serotonin when stimulated with increases in glucose concentration. Serotonin secretion from beta cells decreases cyclic AMP (cAMP) levels in neighboring alpha cells via 5-H ...[more]