Ontology highlight
ABSTRACT:
SUBMITTER: Hong S
PROVIDER: S-EPMC5217864 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hong Sungyoup S Takahashi Haruko H Nadres Enrico T ET Mortazavian Hamid H Caputo Gregory A GA Younger John G JG Kuroda Kenichi K
PloS one 20170106 1
In this report, we demonstrate the pH-dependent, in vitro antimicrobial activity of a cationic, amphiphilic random copolymer against clinical isolates of drug-resistant Staphylococcus aureus. The polymer was developed toward a long-term goal of potential utility in the treatment of skin infections. The proposed mechanism of action of the polymer is through selectively binding to bacterial membranes and subsequent disruption of the membrane structure/integrity, ultimately resulting in bacterial c ...[more]