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Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes.


ABSTRACT: AIMS/INTRODUCTION:Previous studies have suggested a possible relationship between type 2 diabetes mellitus susceptibility loci and diabetic complications. The present study aimed to investigate the associations between type 2 diabetes mellitus loci with peripheral nerve function in a Chinese population with type 2 diabetes mellitus. MATERIALS AND METHODS:A total of 1,900 type 2 diabetes mellitus patients were recruited in the study. We selected ten single nucleotide polymorphisms (SNPs) from ten type 2 diabetes mellitus susceptibility genes previously confirmed in Chinese patients. Genotyping was carried out by using a MassARRAY Compact Analyzer. Peripheral nerve function was evaluated by nerve conduction studies in all participants. The composite Z-scores for nerve conduction parameters including conduction velocity (CV), amplitude and latency were calculated, respectively. RESULTS:Rs5219 of KCNJ11 (E23K, G?A) was identified to be associated with all the parameters obtained from nerve conduction studies (Z-score of CV: ? = 0.113, P = 0.01; Z-score of amplitude: ? = 0.133, P = 0.01; Z-score of latency: ? = -0.116, P = 0.01) after adjustment for covariates including age, duration and glycated hemoglobin. Specifically, each copy of the A allele was related to better outcomes. CDKAL1 rs7756992 and TCF7L2 rs7903146 correlated with the composite Z-score of amplitude (P = 0.028 and P = 0.016, respectively), but not CV (P = 0.393 and P = 0.281, respectively) or latency (P = 0.286 and P = 0.273, respectively). There were no significant associations between the other seven SNPs and peripheral nerve function. CONCLUSIONS:Rs5219 at KCNJ11 (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population.

SUBMITTER: Lu J 

PROVIDER: S-EPMC5217885 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes.

Lu Jingyi J   Luo Yi Y   Wang Jie J   Hu Cheng C   Zhang Rong R   Wang Congrong C   Jia Weiping W  

Journal of diabetes investigation 20160709 1


<h4>Aims/introduction</h4>Previous studies have suggested a possible relationship between type 2 diabetes mellitus susceptibility loci and diabetic complications. The present study aimed to investigate the associations between type 2 diabetes mellitus loci with peripheral nerve function in a Chinese population with type 2 diabetes mellitus.<h4>Materials and methods</h4>A total of 1,900 type 2 diabetes mellitus patients were recruited in the study. We selected ten single nucleotide polymorphisms  ...[more]

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