Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth.

ABSTRACT:

Introduction

Overt thyroid disease in pregnancy is associated with numerous maternal and neonatal complications including preterm birth. Less is known about the contribution of trimester-specific subclinical alterations in individual thyroid hormones, especially in late gestation, on the risk of preterm birth. Herein, we examined the associations between subclinical changes in maternal thyroid hormone concentrations (TSH, total T3, free and total T4), measured at multiple time points in pregnancy, and the odds of preterm birth in pregnant women without clinical thyroid disease.

Participants and methods

Data were obtained from pregnant women participating in a nested case-control study of preterm birth within on ongoing birth cohort study at Brigham and Women's Hospital in Bo

SUBMITTER: Johns LE 

PROVIDER: S-EPMC5217954 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature