Ontology highlight
ABSTRACT:
SUBMITTER: Carson SD
PROVIDER: S-EPMC5218500 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Carson Steven D SD Hafenstein Susan S Lee Hyunwook H
Virology 20161208
Study of coxsackievirus B3 strain 28 (CVB3/28) stability using MOPS to improve buffering in the experimental medium revealed that MOPS (3-morpholinopropane-1-sulfonic acid) increased CVB3 stability and the effect was concentration dependent. Over the pH range 7.0-7.5, virus stability was affected by both pH and MOPS concentration. Computer-simulated molecular docking showed that MOPS can occupy the hydrophobic pocket in capsid protein VP1 where the sulfonic acid head group can form ionic and hyd ...[more]