CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases.
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ABSTRACT:
SUBMITTER: Petroni A
PROVIDER: S-EPMC521914 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
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CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases.
Petroni Alejandro A Melano Roberto G RG Saka Héctor A HA Garutti Alicia A Mange Laura L Pasterán Fernando F Rapoport Melina M Miranda Mariana M Faccone Diego D Rossi Alicia A Hoffman Paul S PS Galas Marcelo F MF
Antimicrobial agents and chemotherapy 20041001 10
The gene bla(CARB-9) was located in the Vibrio cholerae super-integron, but in a different location relative to bla(CARB-7). CARB-9 (pI 5.2) conferred beta-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla(CARB) genes indicated that the CARB enzymes constitute a family of cassette-encoded beta-lactamases. ...[more]
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