Ontology highlight
ABSTRACT:
SUBMITTER: Lin J
PROVIDER: S-EPMC522012 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Lin Jue J Ly Hinh H Hussain Arif A Abraham Mira M Pearl Sivan S Tzfati Yehuda Y Parslow Tristram G TG Blackburn Elizabeth H EH
Proceedings of the National Academy of Sciences of the United States of America 20040915 41
Telomerase synthesizes telomeric DNA by copying a short template sequence within its telomerase RNA component. We delineated nucleotides and base-pairings within a previously mapped central domain of the Saccharomyces cerevisiae telomerase RNA (TLC1) that are important for telomerase function and for binding to the telomerase catalytic protein Est2p. Phylogenetic comparison of telomerase RNA sequences from several budding yeasts revealed a core structure common to Saccharomyces and Kluyveromyces ...[more]