Ontology highlight
ABSTRACT:
SUBMITTER: Cui Z
PROVIDER: S-EPMC5220314 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cui Zhibin Z Shen Yingjia Y Chen Kenny H KH Mittal Suresh K SK Yang Jer-Yen JY Zhang GuangJun G
Scientific reports 20170109
Malignant peripheral nerve sheath tumors (MPNSTs) are a type of rare sarcomas with a poor prognosis due to its highly invasive nature and limited treatment options. Currently there is no targeted-cancer therapy for this type of malignancy. Thus, it is important to identify more cancer driver genes that may serve as targets of cancer therapy. Through comparative oncogenomics, we have found that KANK1 was a candidate tumor suppressor gene (TSG) for human MPNSTs. Although KANK1 is known as a cytosk ...[more]