Ontology highlight
ABSTRACT:
SUBMITTER: Ai J
PROVIDER: S-EPMC5220346 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Ai Jianzhong J Li Jia J Gessler Dominic J DJ Su Qin Q Wei Qiang Q Li Hong H Gao Guangping G
Scientific reports 20170109
Recombinant adeno-associated virus (rAAV) is an attractive tool for basic science and translational medicine including gene therapy, due to the versatility in its cell and organ transduction. Previous work indicates that rAAV transduction patterns are highly dependent on route of administration. Based on this relationship, we hypothesized that intraperitoneal (IP) administration of rAAV produces unique patterns of tissue tropism. To test this hypothesis, we investigated the transduction efficien ...[more]