Brain tau deposition linked to systemic causes of death in normal elderly.
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ABSTRACT:
SUBMITTER: Josephs KA
PROVIDER: S-EPMC5221486 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Brain tau deposition linked to systemic causes of death in normal elderly.
Josephs Keith A KA Tosakulwong Nirubol N Weigand Stephen D SD Murray Melissa E ME Whitwell Jennifer L JL Parisi Joseph E JE Dickson Dennis W DW Petersen Ronald C RC
Neurobiology of aging 20161124
The relationship between causes of death and 4 major neurodegenerative brain proteins (beta-amyloid, tau, alpha-synuclein, and the TAR DNA-binding protein of 43 kDa (TDP-43) were assessed in 94 cognitively normal elderly participants that died without a neurodegenerative disease. There was an association between tau and causes of death (p = 0.01). Tau in the brain was associated with a reduced likelihood of dying from systemic cancers (p = 0.046), and with an increased likelihood of dying from p ...[more]
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