Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress.
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ABSTRACT:
SUBMITTER: Surya VN
PROVIDER: S-EPMC5221531 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress.
Surya Vinay N VN Michalaki Eleftheria E Huang Eva Y EY Fuller Gerald G GG Dunn Alexander R AR
Journal of the Royal Society, Interface 20161201 125
The endothelial cells that line blood and lymphatic vessels undergo complex, collective migration and rearrangement processes during embryonic development, and are known to be exquisitely responsive to fluid flow. At present, the molecular mechanisms by which endothelial cells sense fluid flow remain incompletely understood. Here, we report that both the G-protein-coupled receptor sphingosine 1-phosphate receptor 1 (S1PR1) and its ligand sphingosine 1-phosphate (S1P) are required for collective ...[more]
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