Ontology highlight
ABSTRACT:
SUBMITTER: Piedra FA
PROVIDER: S-EPMC5221584 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Piedra Felipe-Andrés FA Kim Tae T Garza Emily S ES Geyer Elisabeth A EA Burns Alexander A Ye Xuecheng X Rice Luke M LM
Molecular biology of the cell 20160504 22
Microtubules are dynamic polymers of αβ-tubulin that have essential roles in chromosome segregation and organization of the cytoplasm. Catastrophe-the switch from growing to shrinking-occurs when a microtubule loses its stabilizing GTP cap. Recent evidence indicates that the nucleotide on the microtubule end controls how tightly an incoming subunit will be bound (trans-acting GTP), but most current models do not incorporate this information. We implemented trans-acting GTP into a computational m ...[more]