Ontology highlight
ABSTRACT:
SUBMITTER: Szymanski W
PROVIDER: S-EPMC5221732 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Szymanski Wiktor W Ourailidou Maria E ME Velema Willem A WA Dekker Frank J FJ Feringa Ben L BL
Chemistry (Weinheim an der Bergstrasse, Germany) 20150929 46
Cancer treatment suffers from limitations that have a major impact on the patient's quality of life and survival. In the case of chemotherapy, the systemic distribution of cytotoxic drugs reduces their efficacy and causes severe side effects due to nonselective toxicity. Photopharmacology allows a novel approach to address these problems because it employs external, local activation of chemotherapeutic agents by using light. The development of photoswitchable histone deacetylase (HDAC) inhibitor ...[more]